The rule also applies to parenthetical expressions that appear in the middle of a sentence, unless it is a question mark or exclamation point:
If is extremely unlikely that two people (barring identical twins) share precisely
the same gene combinations.
At the science fair, the chemist (or was he more of an alchemist?) turned
red wine into milk before our eyes.
bacon, eggs, and juice
Major reference works on English recommend using the serial comma.
The four most abundant elements in the earth's crust are oxygen,
silicon, aluminum, and iron.